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oenanthotoxin : ウィキペディア英語版
oenanthotoxin

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Oenanthotoxin is a toxin extracted from hemlock water dropwort (''Oenanthe crocata'') and other plants of the genus ''Oenanthe''. It is a central nervous system poison, and acts as a noncompetitive gamma-aminobutyric acid (GABA) antagonist. A case has been made for the presence of this toxin in local ''Oenanthe'' species playing a causative role in euthanasia in ancient Sardinia. It was crystallized in 1949 by Clarke and co-workers.〔E. G. C. Clarke, D. E. Kidder and W. D. Robertson (1949) ''J. Pharm. Pharmacol.'' 1 377-381.〕 It is structurally closely related to the toxins cicutoxin and carotatoxin. Oenanthotoxin is a C17 polyacetylene isomer of cicutoxin.
==Occurrence==

Oenanthotoxin concentration in plants is dependent on seasonal changes and geographical location, the most is present during late winter and early spring.〔 Contrary to most poisonous plants that contain bitter tastes or burning sensations, the water dropwort has a rather sweet and pleasant taste and odor.〔 Water dropwort is characterized by a yellow liquid that changes color due to air exposure.〔〔 The roots are the most toxic part, although the entire plant contains poisonous properties. Unlike the majority of poisonous plants, the poisonous properties are not lost due to plant drying.

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