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paramethadione : ウィキペディア英語版 | paramethadione
Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.〔(Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes ) - Retrieved January 2007.〕 ==Chemistry== Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid. *M.A. Spielman, (1951).
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