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pargyline
Pargyline (Eutonyl) is an irreversible selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 0.01152micromol/L and for MAO-B is 0.00820micromol/L.) It was brought to market in the US and the UK by Abbott in 1963 as "Eutonyl" as an antidepressant, and was one of several other MAO inhibitors brought to market in the 1960s, along with nialamide, isocarboxazid, phenelzine, and tranylcypromine.〔Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685〕〔William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676〕〔Council on Drugs (New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) ) JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.〕
As of 2007 the drug was discontinued〔W. Steven Pray (Interactions Between Nonprescription Products and Psychotropic Medications ) US Pharmacist. 2007;32(11):12-15. 〕 and as of 2014 there were no generic versions in the US.〔FDA (Eutonyl in the Drugs@FDA Database ) Accessed July 19, 2014〕
==See also==
*Rasagiline
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