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Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and an anticholinergic. ==Common use== Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action. Phenyltoloxamine has analgesic and anti-spasmodic properties of its own and is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions. In this respect, it is similar to a closely related antihistamine, orphenadrine, and both drugs are very closely related to diphenhydramine and to doxylamine, the latter of which is the active ingredient in NyQuil and many other cough preparations. Phenyltoloxamine is one of the more effective potentiators of codeine and derivatives such as ethylmorphine, dihydrocodeine, oxycodone, nicocodeine, hydrocodone and similar drugs like tramadol and propoxyphene for all indications, pain relief and cough suppression in particular. Phenyltoloxamine, like diphenhydramine and doxylamine, is an effective non-narcotic anti-tussive on its own but tends to be effective only for productive coughs as the anticholinergic action will exacerbate dry, unproductive coughs, so it is often combined with dextromethorphan, codeine, ethylmorphine, dihydrocodeine, or hydrocodone in cough suppressants both over the counter and prescription. It is also used to discourage abuse in certain opiate analgesics due its unpleasant side effects at high doses. While therapeutic doses of phenyltoloxamine can generate mild to moderate euphoria as can many of its close chemical relatives, much higher doses have a side effect profile similar to that of atropine, which is also used in this fashion for tablets of diphenoxylate and morphine for oral administration. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「phenyltoloxamine」の詳細全文を読む スポンサード リンク
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