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|Section2= }} Plumbagin or 5-hydroxy-2-methyl-1,4-naphthoquinone is an organic compound with the chemical formula . It is regarded as a toxin〔 and it is genotoxic and mutagenic. Plumbagin is a yellow dye,〔(Black Walnut ). Drugs.com.〕 formally derived from naphthoquinone. It is named after the plant genus ''Plumbago'', from which it was originally isolated. It is also commonly found in the carnivorous plant genera ''Drosera'' and ''Nepenthes''. It is also a component of the black walnut drupe (''Juglans nigra''). == Pharmacologic properties == The following properties were described in various cellular and animal models: * antimicrobial, * antimalarial, * anti-inflammatory, * anticarcinogenic, * cardiotonic, * immunosuppressive, * antifertility action, * neuroprotective, * anti-atherosclerosis effects. * Plumbagin has been shown to induce cell cycle arrest and apoptosis in numerous cancer cell lines including melanoma, lung, breast and others. It triggers autophagy via inhibition of the Akt/mTOR pathway and induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. * Plumbagin shows antimicrobial activity〔Dama L.B., Poul B.N.and Jadhav B.V. (1998). Antimicrobial activity of Napthoquinonic compounds. J. Ecotoxicol. Environ. Monit. 8:213-215〕 * Positive inotropic activity〔Poul B.N, Dama L.B.,and Jadhav B.V. (1999). Positive inotropic activity of Plumbagin. D. E. I. J. Sci. Engineering Res. 11: 26-29〕 * Enzymatic spectrum of herbal plants Plumbago Linn.〔Poul B. N., Dama L.B. and Jadhav B. V. (1999). Enzymatic spectrum of herbal Plants ''Plumbago'' Linn. Asian J. Chem. 11(1):273-275〕 * Bioactive spectra of plumbagin.〔Poul B. N., DamaL.B. and Jadhav B. V. (1999). Bioactive spectra of Plumbagin. Asian J. Chem. 11 (1):144-148〕 * Effect on root- knot nematode ''Meloidogyne'' spp.〔Dama L.B. (2002). Effect of naturally occurring napthoquinones on root- knot nematode'' Meloidogyne'' spp. Indian Phytopathology. 55 (1): 67-69〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「plumbagin」の詳細全文を読む スポンサード リンク
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