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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク pracinostat ： ウィキペディア英語版 pracinostat Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor based on hydroxamic acid with potential anti-tumor activity characterized by favorable physicochemical, pharmaceutical, and pharmacokinetic properties. ==Activity== Pracinostat selectively inhibits HDAC class I,II,IV without class III and HDAC6 in class IV,〔(【引用サイトリンク】url=http://www.selleckchem.com/products/SB939.html )〕 but has no effect on other Zn-binding enzymes, receptors, and ion channels. It accumulates in tumor cells and exerts a continuous inhibition to histone deacetylase,resulting in acetylated histones accumulation, chromatin remodeling, tumor suppressor genes transcription, and ultimately, apoptosis of tumor cells. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「pracinostat」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.