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pregnanolone
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Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone; sometimes abbreviated as 3α,5β-THP), also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor,〔 as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects.〔〔 It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.〔
==See also==
* Allopregnanolone
* Hydroxydione
* Isopregnanolone
* Renanolone
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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