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Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. When taken, it is converted to the active metabolite cycloguanil. Proguanil is effective against sporozoites. Proguanil hydrochloride is marketed as Paludrine by AstraZeneca. It has been used for malarial prophylaxis in children with sickle cell disease living in malaria-endemic areas for many years. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. ==Medical uses== Proguanil is usually taken in combination with another antimalarial drug, such as atovaquone (e.g. in the combination Malarone) or chloroquine. Malarone has fewer side effects than mefloquine, but can be more expensive because it is taken daily. Proguanil is taken with atovaquone for chloroquine-resistant and multidrug resistant strains of ''P. falciparum'' and ''P. vivax''. Proguanil combined with atovaquone is sold under the tradename Malarone (GlaxoSmithKline). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「proguanil」の詳細全文を読む スポンサード リンク
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