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pseudopelletierine : ウィキペディア英語版
pseudopelletierine

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Pseudopelletierine is the main alkaloid derived from the root-bark of the pomegranate tree (''Punica granatum''), along with at least three other alkaloids: pelletierine, isopelletierine, and methylpelleteirine (C9H17ON), which yield 1.8, 0.52, 0.01, and 0.20 grams per kilogram of raw bark. Isopelletierine is optically inactive.〔http://library.sciencemadness.org/library/books/the_plant_alkaloids.pdf〕
It is a homolog of tropinone, and can be synthesized in a manner analogous to the classical Robinson tropinone synthesis, using glutaraldehyde (rather than succinaldehyde), acetonedicarboxylic acid, and methylammonium chloride.〔(Pseudopelletierine ), ''Organic Syntheses'', Coll. Vol. 4, p.816 (1963); Vol. 37, p.73 (1957)〕
Pelletierine sulphate is used medicinally in Iraq as an anthelmintic and anti-amoeboid. It triggers, like strychnine, a stimulant reflex, which is effective against tapeworms, ring worms and nematodes. Simple bark-extracts have recently been shown to be effective in vitro against the intestinal bacteria salmonella typhi, vibrio cholera, herpes simplex, HIV, and tumors.〔Mavlyanov S. M., Islambekov S. Y., Karimdzhanov A. K. and Ismailov A. I. (1997), "Polyphenols of pomegranate peels show marked anti-tumor and anti-viral action", Chem. Nat. compounds Vol. 33, pp.98-99.〕〔Zhang J. (1995), "Antiviral activity of tannin from pericarp of Punica granatum against genital Herpes simplex virus in vitro",China Journal of Chinese Materia Medica, Vol. 20, pp.556-558.〕〔http://www.iasj.net/iasj?func=fulltext&aId=47308〕〔El-Sakka M. A. (2010)," phytochemistry alkaloids", 3rd edition〕
== References ==



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