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pyrimethamine
Pyrimethamine (trade name Daraprim) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and to treat ''Toxoplasma gondii'' infections, particularly when combined with the sulfonamide antibiotic sulfadiazine when treating HIV-positive individuals.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
==History==
The Nobel Prize-winning American scientist Gertrude Elion developed the drug at Burroughs-Wellcome (now part of GlaxoSmithKline) to combat malaria. Pyrimethamine has been available since 1953, and is not subject to any unexpired patent.〔FDA AccessData entry for (Pyrimethamine ), accessed September 24, 2015〕 In the United States the market for this product is quite small so no generic manufacturer has emerged. In 2010 GlaxoSmithKline sold the marketing rights for Daraprim to CorePharma and in 2015 the rights were bought by Turing Pharmaceuticals.
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