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radafaxine : ウィキペディア英語版
radafaxine

Radafaxine is drug candidate designated GW-353,162〔(Restless Legs Syndrome: First Approval )〕 by GlaxoSmithKline, investigated for treatment of restless leg syndrome and as an NDRI antidepressant. GlaxoSmithKline was targeting Radafaxine for regulatory filing in 2007,〔( Reviews Novel Therapeutics For CNS Disorders And Confirms Strong Pipeline Momentum - News, Search Jobs, Events )〕 but development was discontinued in 2006 due to "poor test results".〔Independent.co.uk: (GSK breakthrough on bird flu vaccine ).〕
==Chemistry==
It is a potent metabolite of bupropion, the compound in GlaxoSmithKline's Wellbutrin. More specifically, "hydroxybupropion" is an analogue of bupropion, and radafaxine is an isolated isomer ((2S,3S)-) of hydroxybupropion.
Therefore, radafaxine builds on at least some of the properties of bupropion in humans.〔(GlaxoSmithKline Reviews Novel Therapeutics for CNS Disorders and Confirms Strong Pipeline Momentum )〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「radafaxine」の詳細全文を読む



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