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Rebeccamycin is a weak topoisomerase I inhibitor isolated from ''Streptomyces sp.'' It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. It shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). == References == *''Production and biological activity of rebeccamycin, a novel antitumor agent'': J.A. Bush, et al.; J. Antibiot. (Tokyo) 40, 668 (1987) *''Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group'' F. Anizon, et al.; J. Med. Chem. 40, 3456 (1997) *''DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin'': C. Bailly, et al.; Biochemistry 36, 3917 (1997) *''Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition'': C. Bailly, et al.; Chem. Biol. 6, 277 (1999) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「rebeccamycin」の詳細全文を読む スポンサード リンク
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