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Remifentanil (marketed by GlaxoSmithKline and Abbott as Ultiva) is a potent, short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. == Clinical Use == Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time.〔 It has been used effectively during craniotomies,〔Gesztesi Z, Mootz BL, White PF. The use of a remifentanil infusion for hemodynamic control during intracranial surgery. ''Anesth Analg''. 1999;89(5):1282-1287〕 spinal infusions,〔Grottke O, Dietrich PJ, Wiegels S, Wappler F. Intraoperative wake-up test and postoperative emergence in patients undergoing spinal surgery: a comparison of intravenous and inhaled anesthetic techniques using short-acting anesthetics. ''Anesth Analg''. 2004;99(5):1521-1527.〕 cardiac surgery,〔Knapik M, Knapik P, Nadziakiewicz P, et al. Comparison of remifentanil or fentanyl administration during isoflurane anesthesia for coronary artery bypass surgery. ''Med Sci Monit''. 2006;12(8):P133-P138〕 and gastric bypass surgery.〔De Baerdemaeker LEC, Jacobs S, Pattyn P, Mortier EP, Struys MMRF. Influence of intraoperative opioid on postoperative pain and pulmonary function after laparoscopic gastric banding: remifentanil TCI vs sufentanil TCI in morbid obesity. ''Br J Anaesth''. 2007;99(3):404-411.〕 While opiates function similarly, with respect to analgesia, the pharmacokinetics of remifentanil〔Michelsen LG, Hug CC Jr. The pharmacokinetics of remifentanil. J Clin Anesth 1996;8:679–82〕 allows for quicker post-operative recovery.〔Guy J, Hindman BJ, Baker KZ, et al. Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions. ''Anesthesiology''. 1997;86(3):514-524.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「remifentanil」の詳細全文を読む スポンサード リンク
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