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resiniferatoxin : ウィキペディア英語版
resiniferatoxin

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Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (''Euphorbia resinifera''), a cactus-like plant commonly found in Morocco, and in ''Euphorbia poissonii'' found in northern Nigeria.〔(''Euphorbia poissonii'' ) in BoDD – Botanical Dermatology Database〕 It is an ultrapotent analog of capsaicin, the active ingredient in chili pepper.〔
*〕
==Overview==
It activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain). RTX causes an ion channel in the plasma membrane of sensory neurons — the transient receptor potential vanilloid 1 — to become permeable to cations, most particularly the calcium cation; this evokes a powerful irritant effect followed by desensitization and analgesia.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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