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rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene. It is one of the most investigated SNPs of its gene.〔 〕 The C-allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian.〔 The effect of the SNP on the binding potential of the human 5-HT1A neuroreceptor has been assessed with positron emission tomography and the WAY-100635 radioligand, with a study reporting no apparent influence from the SNP.〔 〕 ==Disorders== The SNP has been investigated for association with suicide attempts,〔 〕〔 〕 and psychiatric disorders.〔 One study found an association of the variant with schizophrenia.〔 〕 Some studies associate the G-allele or GG-genotype with depression.〔〔 〕 Not all studies show associations between the disorder and the G-allele. In one study of premenstrual dysphoric disorder C/C was found as the high-risk genotype.〔 〕 Several studies have examine the SNP association with medical treatment response, e.g., antidepressant response in mood disorders, e.g., one study reported worse response for G-allele patients.〔 〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「rs6295」の詳細全文を読む スポンサード リンク
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