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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク sacubitril ： ウィキペディア英語版 sacubitril Sacubitril (INN; developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as ''LCZ696'' and marketed under the brand name, ''Entresto'', is a treatment for heart failure.〔 It was approved under the FDA's priority review process for use in heart failure on July 7, 2015. ==Mechanism of action== Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases.〔 Sacubitrilat inhibits the enzyme neprilysin,〔 which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure-lowering peptides that work mainly by reducing blood volume.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「sacubitril」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.