|
A schistocyte or schizocyte (from Greek ''schistos'' for "divided" or ''schistein'' for "to split", and ''kytos'' for "hollow" or "cell") is a fragmented part of a red blood cell. Schistocytes are typically irregularly shaped, jagged, and have two pointed ends. A true schistocyte does not have central pallor.〔Amanda Cox ''et al.'', (Schistocytes: A Brief Overview ). Retrieved 23 August 2008.〕 Schistocytes are sometimes referred to as "helmet cells". Several microangiopathic diseases, including disseminated intravascular coagulation and thrombotic microangiopathies, generate fibrin strands that sever red blood cells as they try to move past a thrombus, creating schistocytes. Schistocytes are often seen in patients with hemolytic anemia. They are frequently a consequence of mechanical artificial heart valves and hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, among other causes. Excessive schistocytes present in blood can be a sign of microangiopathic hemolytic anemia (MAHA) where the most common cause is aortic stenosis. ==Appearance== Schistocytes are fragmented red blood cells that can take on different shapes. They can be found as triangular, helmet shaped, or comma shaped with pointed edges. Schistocytes are most often found to be microcytic with no area of central pallor. There is usually no change in deformability, but their lifespan is lower than that of a normal red blood cell (120 days). This is due to their abnormal shape which can cause them to undergo hemolysis or be removed by macrophages in the spleen. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「schistocyte」の詳細全文を読む スポンサード リンク
|