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scleredema
Scleredema, also known as Buschke disease, scleredema of Buschke, and scleredema adultorum, is a rare, self-limiting skin condition defined by progressive thickening and hardening of the skin, usually on the areas of the upper back, neck, shoulders and face.〔(【引用サイトリンク】title=Scleredema )〕 The skin may also change color to red or orange. The disease was discovered by Abraham Buschke. Although the cause of scleredema is unknown, it is usually associated with a disease, usually diabetes, a viral illness or strep throat.〔(【引用サイトリンク】title=Scleredema )〕 It is usually not fatal, but it may cause death if the disease spreads to the internal organs.〔 It may also cause an infection.〔
==Diagnosis==
The scleredema is usually proposed as a diagnosis based on the appearance of the skin and the patient's medical history. To confirm the diagnosis, the doctor performs a skin biopsy, in which hematoxylin and eosin staining will show a thick reticular dermis with thick collagen bundles separated by clear spaces. The patient's blood may be examined for diseases that may appear after the onset of symptoms, such as multiple myeloma.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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