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sotalol
Sotalol is a drug used in individuals with rhythm disturbances of the heart (cardiac arrhythmias). It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties.〔Bertrix, Lucien et al. Protection against ventricular and atrial fibrillation by sotalol. Cardiovascular Research 1986; 20, 358-363.〕〔Edvardsson, N et al. Sotalol-induced delayed ventricular repolarization in man. European Heart Journal 1980; 1, 335-343〕 Originally discovered in 1960, sotalol became widely used first as a beta blocker in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.〔Antonaccio M, Gomoll A. Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol. Am J Cardiol 1993; 72, 27A-37A〕 Due to the dual action of sotalol, it is often used preferentially to other beta blockers as treatment for both ventricular fibrillation and ventricular tachycardia.〔〔Dorian P, Newman D. Effect of sotalol on ventricular fibrillation and defibrillation in humans. Am J Cardiol 1993; 72, 72A-79A〕
Trade names for Sotalol include Betapace and Betapace AF (Berlex Laboratories), Sotalex and Sotacor (Bristol-Myers Squibb), and Sotylize (Arbor Pharmaceuticals). The U.S. Food and Drug Administration advises that sotalol only be used for serious arrhythmias, because its prolongation of the QT interval carries a small risk of life-threatening torsade de pointes.〔
==Medical uses==
According to the U.S. Food and Drug Administration (FDA), sotalol can be validly used to maintain normal heart rhythm in people with life-threatening ventricular arrhythmias, or very symptomatic atrial fibrillation or flutter.〔 Due to the risk of serious side effects, the FDA states that sotalol should generally be reserved for patients whose ventricular arrhythmias are life-threatening, or whose fibrillation/flutter cannot be resolved using the Valsalva maneuver or another simple method.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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