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Sucralfate is a medication primarily taken to treat active duodenal ulcers. Sucralfate is also used for the treatment of gastroesophageal reflux disease (GERD) and stress ulcers. Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus. It also promotes bicarbonate production and acts like an acid buffer with cytoprotective properties. Brand names include Carafate in U.S.A., Sucramal in Italy, Sufrate, Sucralcoat, Pepsigard, Sucral, Sucrafil, Hapifate in India, Sutra or Musin in parts of South-East Asia, Sulcrate in Canada, Ulsanic in South Africa and Israel, and Antepsin in Turkey. ==Medical uses== Sucralfate is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs), as the mechanism behind these ulcers is due to acid oversecretion. It is not FDA approved for gastric ulcers, as the main mechanism is not due to acid oversecretion but rather from diminished protection. The use for sucralfate in peptic ulcer disease has diminished recently, but it is still the preferred agent for stress ulcer prevention. Sucralfate has also been used for the following conditions: * Active duodenal ulcer not related to NSAID use * Maintenance therapy for resolved duodenal ulcers * Gastric ulcer not related to NSAID use and gastritis due to GERD. Triple combination therapy with lansoprazole + cisapride + sucralfate can significantly improve symptoms and quality of life and was more cost-effective than ranitidine combination group. * Aphthous ulcer and stomatitis due to radiation or chemotherapy * Proctitis from radiation or ulcerative colitis * Gastro-esophageal reflux disease during pregnancy -- first-line drug therapy combined with lifestyle and diet modification. * Stress ulcer prophylaxis—The use of sucralfate rather than H2 antagonists for stress ulcer prophylaxis, and measures to prevent aspiration, such as continuous subglottic suctioning, have been shown to reduce the risk of ventilator-associated pneumonia (VAP). * Prevention of stricture formation—sucralfate has an inhibitory effect on stricture formation in experimental corrosive burns and can be used in the treatment of corrosive esophageal burns to enhance mucosal healing and suppress stricture formation * Rectal bleeding and its management after irradiation for uterine cervical cancer * * Grade 1 bleeding experienced immediate relief with sucrasulfate enema for 1 month. * * Grade 2 bleeding, sucrasulfate enema and/or coagulation were effective. * * Grade 3 bleeding lasted for 1 year despite frequent transfusions and coagulation. * * Grade 2 and 3 rectal bleeding occurred in 8.5% of people. The most significant risk factor was the ICRU-CRBED. Prompt treatment with a combination of sucrasulfate enema and coagulation is effective in controlling Grade 1 and 2 rectal bleeding without the development of fistula or stricture. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「sucralfate」の詳細全文を読む スポンサード リンク
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