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tetanospasmin
Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of ''Clostridium tetani'' in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, or TeNT. The LD50 of this toxin has been measured to be approximately 1 ng/kg, making it second only to Botulinum toxin as the deadliest toxin in the world.〔(【引用サイトリンク】url=http://www.ehs.ufl.edu/programs/bio/toxins/ )〕 However, these tests are conducted solely on mice which may react to the toxin differently from humans and other animals.
''C. tetani'' also produces the exotoxin tetanolysin, a hemolysin, that causes destruction of tissues.
==Distribution==
Tetanus toxin spreads through tissue spaces into the lymphatic and vascular systems. It enters the nervous system at the neuromuscular junctions and migrates through nerve trunks and into the central nervous system (CNS) by retrograde axonal transport by using dyneins.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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