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tetrahydrogestrinone
Tetrahydrogestrinone〔US Patent Application 2006/45847〕(often referred to as THG or The Clear) is an anabolic steroid developed by Patrick Arnold.〔 It has affinity to the androgen receptor and the progesterone receptor, but not to the estrogen receptor.
Developed completely in secret by Patrick Arnold, the drug was used in performance enhancement without having been studied for side-effects. The drug has been considered a designer drug, closely related to the banned anabolic steroids gestrinone and trenbolone,〔(Oct.2003 FDA statement on THG )〕 and was referred to as an unapproved new drug by the Food and Drug Administration (FDA) in 2003 before the subsequent scheduling of it in 2005. A synthesis was devised to ensure a source of material for comparison.〔US2006045847 - Method for determination of anabolic activity〕 The drug has never entered legitimate medical use, although some studies have been made of its properties and toxicity. Concerns have also been raised about its potential use in horse-racing and other veterinary contexts.
==Pharmacology==
Structure-activity relationship studies report that the potency of the drug is outstanding, surpassing, on a milligram per milligram basis, every known synthesized or commercial available anabolic steroid at the time of its development. It is a highly potent agonist for the androgen and progesterone receptors, around 10 times more potent than the comparison drugs nandrolone or trenbolone, but with no estrogenic activity. It has been found to bind to the androgen receptor with similar affinity to dihydrotestosterone and produces growth of muscle tissue. According to Patrick Arnold, due the drug's potency, he never had to supply significant quantities to BALCO, because "just a couple of drops under the tongue" were a sufficient dose.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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