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ticlopidine
Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare but serious side effects of neutropenia and thrombotic thrombocytopenic purpura it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited.
== History ==
Ticlopidine was discovered incidentally in the 1970s while trying to develop a new anti-inflammatory medication. Pharmacology developers noted that this new compound had strong anti-platelet properties. In 1978 it began to be marketed in France for patients at high risk for thrombotic events: postoperative cardiac patients, patients undergoing hemodialysis, peripheral vascular disease, and the prevention of strokes and ischemic heart disease.
Ticlopidine was introduced to the United States under the trade name Ticlid by Roche after it was FDA approved in 1991. The first generic ticlopidine hydrochloride was FDA approved in 1999. As of April 2015, Roche, Caraco, Sandoz, Par, Major, Apotex, and Teva had discontinued generic ticlopidine and no ticlopidine preparations were available in the US.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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