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Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer, and other cancer types. After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15, 2007, topotecan is the first topoisomerase I inhibitor for oral use. ==Indications (approved uses)== * Ovarian cancer (FDA May 1996).〔http://www.fda.gov/bbs/topics/NEWS/NEW00537.html〕 * Cervical cancer (FDA June 2006).〔http://www.cancer.gov/cancertopics/druginfo/fda-topotecan-hydrochloride〕〔http://www.fda.gov/CDER/Offices/OODP/whatsnew/topotecan.htm FDA〕 * Small cell lung cancer (SCLC) (FDA Oct 2007).〔http://onctalk.com/2007/12/18/oral-topotecan-fda-approved/〕〔http://www.drugs.com/newdrugs/gsk-receives-approval-hycamtin-topotecan-capsules-relapsed-small-cell-lung-cancer-671.html Press release〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「topotecan」の詳細全文を読む スポンサード リンク
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