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| trandolapril ： ウィキペディア英語版 |
trandolapril
Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions.
It is marketed by Abbott Laboratories with the brand name Mavik.
== Pharmacology ==
Trandolapril is a prodrug that is de-esterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half-life of about 6 hours, and trandolaprilat has a half life of about 10 h. Trandolaprilat has about eight times the activity of its parent drug. About one-third of trandolapril and its metabolites are excreted in the urine, and about two-thirds of trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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