| 翻訳と辞書 |
translocon
The translocon (commonly known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes. In eukaryotes the term translocon most commonly refers to the complex that transports nascent polypeptides with a targeting signal sequence into the interior (cisternal or lumenal) space of the endoplasmic reticulum (ER) from the cytosol. This translocation process requires the protein to cross a hydrophobic lipid bilayer. The same complex is also used to integrate nascent proteins into the membrane itself (membrane proteins). In prokaryotes, a similar protein complex transports polypeptides across the plasma membrane or integrates membrane proteins. Bacterial pathogens can also assemble other translocons in their host membranes, allowing them to export virulence factors into their target cells.
==The prokaryotic translocon==
The bacterial translocation channel is formed by a trimeric protein complex called SecYEG. It consists of the subunits SecY, SecE, and SecG. The structure of the archaeal homolog of this complex has been determined by X-ray crystallography. There has been a long-standing debate about the oligomeric state of the complex in the cell. Most recently, the monomeric form seems to be favored by most researchers.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「translocon」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|