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trifluoromethylphenylpiperazine : ウィキペディア英語版
trifluoromethylphenylpiperazine

3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class. Usually in combination with its analogue benzylpiperazine (BZP), it is sold as a alternative to the illicit drug MDMA ("Ecstasy") under the name "Legal X".〔(【引用サイトリンク】title=Erowid TFMPP Vault: Basics )
== Pharmacology ==
TFMPP has affinity for the 5-HT1A (Ki = 288 nM), 5-HT1B (Ki = 132 nM), 5-HT1D (Ki = 282 nM), 5-HT2A (Ki = 269 nM), and 5-HT2C (Ki = 62 nM) receptors, and functions as a full agonist at all sites except the 5-HT2A receptor, where it acts as a weak partial agonist or antagonist. Unlike the related piperazine compound ''meta''-chlorophenylpiperazine (mCPP), TFMPP has insignificant affinity for the 5-HT3 receptor (IC50 = 2,373 nM). TFMPP also binds to the SERT (EC50 = 121 nM) and evokes the release of serotonin.〔 It has no effects on dopamine or norepinephrine reuptake or efflux.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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