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trovafloxacin
Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) was a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones.
==Adverse reactions==
Trovafloxacin use is significantly restricted due to its high potential for inducing serious, sometimes fatal liver damage.〔(【引用サイトリンク】title=Acute liver failure due to trovafloxacin: CT findings )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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