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tuberculin
Tuberculin is an extract of ''Mycobacterium tuberculosis'', ''M. bovis'', or ''M. avium'' that is used in skin testing in animals and humans to identify a tuberculosis infection. Several types of tuberculin have been used for this, of which purified protein derivative (PPD) is the most important. PPD is a poorly defined, complex mixture of antigens. Tests based upon PPD are relatively unspecific since many of its proteins are found in different mycobacterial species.
== Development history ==
Tuberculin was discovered by German scientist and physician Robert Koch in 1890. The original tuberculin discovered by Koch was a glycerine extract of the tubercle bacilli and was developed as a remedy for tuberculosis, but it was ineffective in this role. Clemens von Pirquet, an Austrian physician, discovered that patients who had previously received injections of horse serum or smallpox vaccine had quicker, more severe reactions to a second injection, and he coined the word ''allergy'' to describe this hypersensitivity reaction. Soon thereafter von Pirquet discovered the same type of reaction took place in those infected with tuberculosis, and he thus found the utility of what would become the tuberculin skin test. Individuals with active tuberculosis were usually tuberculin positive, but many of those with disseminated and rapidly progressive of disease were negative. This led to the widespread but erroneous belief that tuberculin reactivity is an indicator of immunity to tuberculosis.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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