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valganciclovir
Valganciclovir (Valcyte, manufactured by Hoffmann–La Roche, and also known as Cymeval, Valcyt, Valixa, Darilin, Rovalcyte, Patheon, and Syntex〔(Drugs.about list of names for valganciclovir )〕) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir.〔Sugawara M, Huang W, Fei YJ, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000;89(6):781-9.〕 After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
== Administration ==
Orally, available in 450 mg tablets. For patients who have received a transplant, the recommended dose is 900 mg once daily, starting within 10 days of transplantation and continuing for 6 months post transplantation. HIV patients might initially need to take the dose 900 mg twice daily for the first 3 weeks.〔(electronic Medicines Compendium )〕
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