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Vasomotion is the spontaneous oscillation in tone of blood vessels, independent of heart beat, innervation or respiration.〔Haddock RE, Hill CE. Rhythmicity in arterial smooth muscle. J Physiol (Lond ). 2005; 566: 645-656,Aalkaer C, Nilsson H. Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br J Pharmacol. 2005; 144: 605-616.〕 While vasomotion was first observed by Jones in 1852, the complete mechanisms responsible for its generation and its physiological importance remain to be elucidated, however several hypotheses have been put forth.〔Aalkaer C, Nilsson H. Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br J Pharmacol. 2005; 144: 605-616.〕 ==Mechanism== Intracellular calcium (Ca2+) concentration exhibits periodic oscillations in vascular smooth muscle cells. This is thought to result from Ca2+ release from intracellular stores, due to inositol triphosphate and ryanodine-sensitive channel activation. This activation has been shown to result in either Ca2+ "sparks", highly localized calcium increases, or "waves", global Ca2+ increase that propagates the length of the cell.〔Jaggar JH, Porter VA, Lederer WJ, Nelson MT. Calcium sparks in smooth muscle. Am J Physiol Cell Physiol. 2000; 278: C235-256.〕 To allow vasomotion to occur, synchronization must occur between the individual oscillations, resulting in global calcium synchronization and vessel tone oscillation.〔Nilsson H, Aalkjaer C. Vasomotion: mechanisms and physiological importance. Molecular Interventions. 2003; 3: 79-89.〕 Gap junctions are thought to play a large role in this synchronization, as application of gap junction blockers has been shown to abolish vasomotion, indicating a critical role.〔Haddock RE, Hirst GDS, Hill CE. Voltage independence of vasomotion in isolated irideal arterioles of the rat. J Physiol. 2002; 540: 219-229.〕 Due to regional variations in gap junction distribution and coupling (homocellular vs. heterocellular) several hypotheses have been suggested to account for vasomotion occurrence. The "classic" mechanism of vasomotion generation is thought to be the voltage-dependent coupled model.〔 In this model, high gap junction coupling is present between the vascular smooth muscle cells, the endothelial cells and the endothelial to vascular smooth muscle cells. An initial depolarizing current leads to the opening of the voltage-dependent calcium channels, ultimately resulting in synchronization of individual calcium levels. When patch clamp recordings are conducted, depolarization occurs in the endothlial layer at the same time as the underlying vascular smooth muscle. The cause of the initial depolarizing current, however, remains to be determined. Mathematical modeling has pointed to the existence of 2-4 independent non-linear oscillating systems interacting to produce vasomotion.〔Parthimos D, Haddock RE, Hill CE, Griffith TM. Dynamics of A Three-Variable Nonlinear Model of Vasomotion: Comparison of Theory and Experiment. Biophys J. 2007; 93: 1534-1556.〕 It is possible that in order for vasomotion to be generated, these systems must pass a depolarizing threshold. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「vasomotion」の詳細全文を読む スポンサード リンク
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