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visilizumab
Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease. PDL BioPharma, Inc. canceled production of visilizumab following its Phase II/III clinical trials, citing its inefficacy and poor safety profile compared to other drugs on the market as the major reasons.〔(【引用サイトリンク】 PDL Lands in a Hazard )〕 Nevertheless, clinical trials continue for various diseases like multiple myeloma and diabetes mellitus type 1 . Visilizumab has also been radiolabelled with technetium-99m for imaging T cells. ==References==
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