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2-acyl-sn-glycero-3-phosphocholines are a class of phospholipids that are intermediates in the metabolism of lipids. Because they result from the hydrolysis of an acyl group from the ''sn-1'' position of phosphatidylcholine, they are also called 1-lysophosphatidylcholine (or 1-lysoPC, in short). The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product. Other synonyms for this class of compounds are 2-acylglycero-3-phosphocholine, 1-lyso-2-acyl-sn-glycero-3-phosphocholine, β-lysophosphatidylcholine, 2-acylglycerophosphocholine, L-1-lysolecithin and 1-lecithin. ==Chemical properties== 1-LysoPC can convert to the structurally similar 2-lysoPC. This happens by the migration of the acyl group from the ''sn-1'' position of the glycerol backbone to the ''sn-2'' position. The lowest rate of isomerization is at pH 4-5. Starting from either 1-lysoPC or 2-lysoPC, an equilibrium mixture of 90% 2-lysoPC and 10% 1-lysoPC is obtained with a half-time of about 10 minutes under physiological conditions〔(PMID 10600639 )〕 and about 1 hour under typical laboratory conditions. Thus, unless special care is taken to slow this isomerization reaction, characterization of either of these lipids using laboratory assays that take a significant amount of time is likely to produce results on a mixture of the two lipids.〔 In the fungus Penicillium notatum'', an enzyme called lysolecithin acylmutase has been reported that can catalyze this isomerization reaction at low pHs at which the uncatalyzed reaction occurs very slowly. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「1-Lysophosphatidylcholine」の詳細全文を読む スポンサード リンク
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