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124I-PGN650
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124I-PGN650 : ウィキペディア英語版
124I-PGN650

124I-PGN650 is a phosphatidylserine-(PS)-targeting F(ab')2 fully human monoclonal antibody fragment (derived from PGN635) joined to the PET imaging radio-isotope iodine-124 (124I) that is currently evaluated in an exploratory trial for cancer imaging. PS is a molecule usually located inside the membrane of healthy cells, but "flips" and becomes exposed on the outside of cells that line tumor blood vessels, creating a specific target for the imaging of multiple solid tumor types. In preclinical studies, 124I-PGN650 accumulates in tumor vasculature and provides ''in vivo'' tumor images. Additionally, chemotherapies and radiation therapy increase the amount of exposed PS on tumor blood vessels.〔http://www.peregrineinc.com/pipeline/pgn650-tumor-imaging.html〕
==Exploratory study==
In April 2012, Peregrine Pharmaceuticals launched its experimental PS-targeting molecular imaging candidate, 124I-PGN650, into clinical development for the imaging of multiple solid tumor types. The primary goal of this trial is to estimate radiation dosimetry in critical and non-critical organs. Secondary objectives of the trial are tumor imaging and safety. As of June 8, 2014, the estimated date of completion of this trial is August 2015.〔http://clinicaltrials.gov/show/NCT01632696〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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