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18,19-Dehydrobuprenorphine
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18,19-Dehydrobuprenorphine : ウィキペディア英語版
18,19-Dehydrobuprenorphine

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18,19-Dehydrobuprenorphine (HS-599) is a derivative of buprenorphine. It has about twice the potency of buprenorphine. It has produced a long-lasting antinociceptive response in animal tests.〔(HS-599: a novel long acting opioid analgesic )〕
18,19-Dehydrobuprenorphine never induced conditioned place-preference in test animals, unlike buprenorphine and morphine.〔
18,19-Dehydrobuprenorphine has about three times higher affinity for the μ-opioid receptor but lower affinity for δ- and κ-opioid receptors when compared with buprenorphine.〔〔( SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF18,19-DEHYDROBUPRENORPHINE ) Archive.org〕
==References==




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